Interaction of Haemophilus Influenzae with Complement

摘要: H. influenzae, whether capsulated or not, is able to activate both the classical and alternative pathways (Anderson et al, 1972; Quinn 1977) resulting in potential generate bactericidal opsonising activities. Most studies have investigated these activities relationship type b strains because of importance this serotype as a cause life-threatening invasive infections childhood. Anderson al (1972) showed that either purified capsular polysaccharide (PRP) non-capsulated influenzae organisms could absorb factors from human serum which were necessary for complement dependent activity. Subsequent by Steele used affinity IgG antibodies agammaglobulinaemic factor D properdin had been selectively inactivated demonstrate be killed through pathway mediated PRP. Similarly, activity also demonstrated using an fraction sera pre-adsorbed with PRP remove anticapsular antibodies. Taken together, suggested capsule cell envelope constituents are