Two Residues in NSP9 Contribute to the Enhanced Replication and Pathogenicity of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus.
作者： Kuan Zhao , Jia-Cong Gao , Jun-Yao Xiong , Jin-Chao Guo , Yong-Bo Yang
DOI: 10.1128/JVI.02209-17
关键词: Biology 、 Mutant 、 Virulence 、 Virus 、 Amino acid 、 Strain (biology) 、 Complementary DNA 、 Virology 、 Porcine reproductive and respiratory syndrome virus 、 Viral load
摘要: … the increased virulence of HP-PRRSV. These data will contribute to a better understanding of the molecular mechanisms of HP-PRRSV replication and pathogenicity and may lead to …
sci-hub.se 参考文章(31)
E Albina, Y Leforban, P Vannier, J Plana Duran, H Guilmoto, T Baron, F Madec, Report on the first outbreaks of the porcine reproductive and respiratory syndrome (PRRS) in France. Diagnosis and viral isolation Annals of veterinary research. ,vol. 23, pp. 161- 166 ,(1992)
Li Gao, Lianghai Wang, Chen Huang, Longlong Yang, Xue-Kun Guo, Zhibin Yu, Yihao Liu, Peng Yang, Wen-hai Feng, HP-PRRSV is attenuated by de-optimization of codon pair bias in its RNA-dependent RNA polymerase nsp9 gene. Virology. ,vol. 485, pp. 135- 144 ,(2015) , 10.1016/J.VIROL.2015.07.012
Kenneth K.-S. Ng, Jamie J. Arnold, Craig E. Cameron, Structure-Function Relationships Among RNA-Dependent RNA Polymerases Current Topics in Microbiology and Immunology. ,vol. 320, pp. 137- 156 ,(2008) , 10.1007/978-3-540-75157-1_7
Debin Tian, Xiang-Jin Meng, Amino acid residues Ala283 and His421 in the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus play important roles in viral ribavirin sensitivity and quasispecies diversity. Journal of General Virology. ,vol. 97, pp. 53- 59 ,(2016) , 10.1099/JGV.0.000316
Yuli He, Gang Wang, Yonggang Liu, Wenda Shi, Zifeng Han, Jianan Wu, Chenggang Jiang, Shujie Wang, Shouping Hu, Huiqiang Wen, Jianguo Dong, He Liu, Xuehui Cai, Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus Veterinary Microbiology. ,vol. 160, pp. 455- 462 ,(2012) , 10.1016/J.VETMIC.2012.05.040
Y. Fang, E. E. Treffers, Y. Li, A. Tas, Z. Sun, Y. van der Meer, A. H. de Ru, P. A. van Veelen, J. F. Atkins, E. J. Snijder, A. E. Firth, Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 17321- 17322 ,(2012) , 10.1073/PNAS.1211145109
Haihong Zheng, Zhi Sun, Xing-Quan Zhu, Jinxue Long, Jiaqi Lu, Jian Lv, Shishan Yuan, Recombinant PRRSV expressing porcine circovirus sequence reveals novel aspect of transcriptional control of porcine arterivirus Virus Research. ,vol. 148, pp. 8- 16 ,(2010) , 10.1016/J.VIRUSRES.2009.11.014
Mingyuan Han, Dongwan Yoo, Engineering the PRRS virus genome: updates and perspectives. Veterinary Microbiology. ,vol. 174, pp. 279- 295 ,(2014) , 10.1016/J.VETMIC.2014.10.007
Z. Han, Y. Liu, G. Wang, Y. He, S. Hu, Y. Li, W. Shi, J. Wu, S. Wang, H. Liu, X. Cai, Comparative Analysis of Immune Responses in Pigs to High and Low Pathogenic Porcine Reproductive and Respiratory Syndrome Viruses Isolated in China. Transboundary and Emerging Diseases. ,vol. 62, ,(2015) , 10.1111/TBED.12190
Ying Fang, Eric J. Snijder, The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins. Virus Research. ,vol. 154, pp. 61- 76 ,(2010) , 10.1016/J.VIRUSRES.2010.07.030