Differential uptake of and sensitivity to diphenhydramine in embryonic and larval zebrafish.
作者： Lauren A. Kristofco , Samuel P. Haddad , C. Kevin Chambliss , Bryan W. Brooks
DOI: 10.1002/ETC.4068
关键词: Embryo 、 Toxicodynamics 、 Zebrafish 、 Embryonic stem cell 、 Diphenhydramine 、 Andrology 、 Toxicokinetics 、 Chemistry 、 Zebrafish larvae 、 Toxicity
摘要: The zebrafish fish embryo toxicity (FET) test is increasingly employed for alternative studies, yet our previous research identified increased sensitivity of slightly older than embryos in FET methods (0-4 d postfertilization [dpf]). We rapid steady-state accumulation diphenhydramine across and larval stages. However, significantly (p < 0.05) lower was observed at 48 h compared to 96 h chorionated dechorionated dpf), but not 7 11 14 18 dpf. Increased uptake further 18 dpf with 0-4 chorion or dechorionated, which indicates that differential age associated resulting from gill other toxicokinetic toxicodynamic changes during development. Environ Toxicol Chem 2018;37:1175-1181. © 2017 SETAC.
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