Physiological significance of apoptosis during animal virus infection
作者： A. HAJIME KOYAMA , AKIO ADACHI , HIROSHI IRIE
关键词: Virus 、 Tumor necrosis factor alpha 、 Animal virus 、 Biology 、 Apoptosis 、 Viral replication 、 Host Defense Mechanism 、 Viral shedding 、 Virus Physiological Phenomena 、 Virology
摘要: Apoptosis has been considered to be a host defense mechanism against viral infection in multicellular organisms. This is based on the findings that apoptogenic mutants of insect viruses cannot grow because infected cells die by apoptosis. suggests apoptotic response deleterious effect virus infection. Thus, apoptosis an important capable inhibiting replication during However, vitro studies indicated alone does not provide same protection animal as it cells. Still, most have acquired strategy overcome cell In addition, varying degree necrosis usually accompanies apoptosis, suggesting possible contribution reactions virus. To understand physiological significance infection, we characterized growth and cellular responses wide variety virus-cell interaction systems. Mainly our own works, discuss nature verify its role
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