Yersinia pestis plasminogen activator gene homolog in rat tissues.

摘要: To the Editor: Yersinia pestis causes plague, which primarily affects rodents, but is an invasive and virulent pathogen among humans. Y. infection endemic in small rodent populations different parts of world, bacterium considered a potential bioweapon because it can be easily isolated, produced, dried, dispersed as aerosol. Antimicrobial drug treatment lifesaving during early stages illness; hence, rapid sensitive methods for detection environmental clinical samples are required. Multiple PCR assays that detect markers located on plasmids have been developed (1–6). The plasminogen activator/coagulase (pla) gene, plasmid pPCP1, incorporated into most assays, several studies was prime or sole marker (1,2,5,7–9). Reasons including pla these its occurrence multiple copies, absence from closely related species, role virulence (1,4,5).