Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

摘要: Abstract Lung cancer has one of the highest mortality rates among various types and is most frequent in world. The incidence lung increasing rapidly, parallel with an increased smoking. Effective chemoprevention may be alternative strategy to control cancer. Thus, objective current work was ascertain possible preventive therapeutic efficacies Cuphea ignea extract a mouse model tumorigenesis its cytotoxicity toward A549 human cell line. induced by oral administration benzo(a)pyrene (50 mg/kg b.w.) twice per week Swiss albino mice for 4 weeks. Benzo(a)pyrene-treated were orally administered C. (300 mg/kg body weight, 5 days/week) 2 weeks before or 9 after first dose, total 21 At end period, parameters measured serum tissues. results revealed that resulted increases relative levels tumor markers (ADA, AHH, LDH), inflammatory marker NF-κB, decreased antioxidant capacity compared control. In addition, enzymatic non-enzymatic antioxidants, concomitant increase lipid peroxidation, metalloproteinases (MMP-2 MMP-12), angiogenic VEGF detected Moreover, upregulation PKCα, COX-2, Bcl-2 expression, downregulation BAX caspase-3 expression. treatment alleviated all alterations these parameters, which further confirmed histopathological analysis findings provide verification potentials against benzo(a)pyrene-induced mice.