Meta-analysis of heterogeneously reported trials assessing change from baseline.

作者: Keith R. Abrams , Clare L. Gillies , Paul C. Lambert

DOI: 10.1002/SIM.2423

关键词: Meta-analysisBaseline (configuration management)StatisticsComputer scienceBayesian probabilityCorrelationIntervention effectSystematic reviewEconometricsSensitivity (control systems)Physical functioning

摘要: This paper considers the quantitative synthesis of published comparative study results when outcome measures used in individual studies and way which they are reported varies between studies. Whilst former difficulty may be overcome, at least to a limited extent, by use standardized effects, latter is often more problematic. Two potential solutions this problem are; sensitivity analyses fully Bayesian approach, pertinent external information included. Both approaches illustrated using two systematic reviews meta-analyses consider difference mean change systolic blood pressure physical functioning an intervention control group. The examples illustrate that adopting as opposed undertaking assuming fixed values for unknown parameters, overall effect can estimated with greater uncertainty, but assessing choice prior distributions such crucial.

参考文章(43)
TX Station, Stata Statistical Software: Release 7. 0 College Stata Corporation. ,(2001)
Alex J Sutton, Keith R Abrams, David R Jones, Trevor A Sheldon, Fujian Song, Methods for Meta-Analysis in Medical Research ,(2000)
Jonathan J Deeks, Douglas G Altman, Michael J Bradburn, Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta‐Analysis John Wiley & Sons, Ltd. pp. 285- 312 ,(2008) , 10.1002/9780470693926.CH15
Francesca Dominici, Scott L. Zeger, Giovanni Parmigiani, Joanne Katz, Parul Christian, Does the effect of micronutrient supplementation on neonatal survival vary with respect to the percentiles of the birth weight distribution Bayesian Analysis. ,vol. 2, pp. 1- 30 ,(2007) , 10.1214/07-BA201
Francesco P Cappuccio, Sally M Kerry, Lindsay Forbes, Anna Donald, Blood pressure control by home monitoring: meta-analysis of randomised trials BMJ. ,vol. 329, pp. 145- 148 ,(2004) , 10.1136/BMJ.38121.684410.AE
J Deeks, J Dinnes, R D'Amico, A Sowden, C Sakarovitch, F Song, M Petticrew, D Altman, Evaluating non-randomised intervention studies. Health Technology Assessment. ,vol. 7, pp. 1- 173 ,(2003) , 10.3310/HTA7270