Does the effect of micronutrient supplementation on neonatal survival vary with respect to the percentiles of the birth weight distribution

摘要: Scientic Background: In developing countries, higher infant mortality is partially caused by poor maternal and fetal nutrition. Clinical trials of micronutrient supplementation are aimed at reducing the risk increasing birth weight. Because greatest among low weight infants (LBW) ( 2500 grams), an eectiv e intervention may need to increase smallest babies. Although it has been demonstrated that increases in a trial conducted Nepal, there inconclusive evidence improves their survival. It hypothesized potential benet treatment on survival LBW partly compensated null or even harmful eect largest infants. Exploratory analyses have suggested might vary with respect percentiles distribution. Data: The methods this paper motivated double-blind randomized community rural Nepal (Christian et al 2003a,b). investigators implemented program evaluate benets following supplementations: folic acid vitamin A (F+A); acid, iron, (F+I+A); zinc, (F+I+Z+A); multiple nutrients (M+A). Each supplement was administered daily 1000 pregnant women, who ultimately delivered approximately 800 live-born team measured within 72 hours delivery then followed for one year determine whether not they survived. addition, several characteristics mother (maternal age, height, arm circumference) (weight, length, head chest circumference).