Maternal low-dose vitamin A or β-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal

摘要: BACKGROUND The effect of vitamin A supplementation on the survival infants aged <6 mo is unclear. Because most infant deaths occur in first few month life, maternal may improve survival. OBJECTIVES objective was to assess or beta-carotene fetal loss and age. DESIGN Married women reproductive age 270 wards Sarlahi district, Nepal, were eligible participate. Wards randomly assigned have receive weekly doses 7000 microg retinol equivalents as retinyl palmitate (vitamin A), 42 mg all-trans-beta-carotene, placebo. Pregnancies followed until miscarriage, stillbirth, death, live birth one more infants, who through 24 wk RESULTS total 43559 enrolled; 15832 contributed 17373 pregnancies 15987 born trial. rate 92.0/1000 placebo group, comparable with rates groups, which had relative risks 1.06 (95% CI: 0.91, 1.25) 1.03 0.87, 1.19), respectively. 24-wk mortality 70.8/1000 births 1.05 0.86, 1.22), CONCLUSIONS Small given before conception, during pregnancy, postpartum did not early Nepal.