MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1
作者： QIZHUANG LI , QUAN CHENG , ZIGUI CHEN , RENJUN PENG , RUI CHEN
DOI: 10.3892/OR.2015.4432
关键词: Immunology 、 Cell 、 Biology 、 Cell cycle 、 MMP2 、 Oncogene 、 Epithelial–mesenchymal transition 、 Cell migration 、 microRNA 、 Cancer research 、 U87
摘要: Cell migration and invasion are key processes involved during tumor metastasis. Recently, microRNAs (miRs) have been demonstrated to play important roles in the regulation of cancer However, underlying mechanisms remain unknown. Here, we aimed investigate exact role miR-663 metastasis glioblastoma as well mechanisms. By performing quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis, that was significantly downregulated tissues (n=25), when compared normal brain (n=15). In addition, its expression levels were also reduced human cell lines, A172 U87. Furthermore, restoration led a significant decrease proliferation, U87 cells. We further identified TGF-β1 direct target miR-663, found negatively mediated by at post-transcriptional level Moreover, overexpression reversed inhibitory effects upregulation on our data suggest MMP2 E-cadherin, factor epithelial-mesenchymal transition (EMT), miR-633/TGF-β1-mediated glioblastoma. summary, plays an cells, partly least, via mediation downstream E-cadherin. Therefore, is potential candidate for prevention
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