Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma
作者： Shaoqiang Liang , Ning Zhang , Yanming Deng , Lusi Chen , Yang Zhang
DOI: 10.1155/2016/7648215
关键词:
摘要: MicroRNAs (miRs) play crucial roles in the carcinogenesis and malignant progression of human cancers including nasopharyngeal carcinoma (NPC). In this study, we aimed to investigate association serum miR-663 levels with clinical factors prognosis NPC patients. Real-time PCR was performed examine amount patients healthy controls. Our data showed that significantly higher than Moreover, were correlated grade, lymph node metastasis, stage NPC. Furthermore, closely associated worse 5-year overall survival (OS) relapse-free (RFS) NPC, level found be an independent predicator for addition, after receiving chemoradiotherapy, reduced summary, upregulated patients, which downregulated its increased poor Therefore, may become a potential outcome
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core.ac.uk 参考文章(33)
He-Qin Cui, Guang-Ling Zhang, Zhi-Yong Liu, Ya-Nan Xiong, Mei-Mei Wang, MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation Asian Pacific Journal of Cancer Prevention. ,vol. 12, pp. 2819- 2823 ,(2011)
Li Jiao, Zhen Deng, Chuanliang Xu, Yongwei Yu, Yun Li, Chun Yang, Junyi Chen, Zhiyong liu, Gang Huang, Long-Cheng Li, Yinghao Sun, miR‐663 Induces Castration‐Resistant Prostate Cancer Transformation and Predicts Clinical Recurrence Journal of Cellular Physiology. ,vol. 229, pp. 834- 844 ,(2014) , 10.1002/JCP.24510
Chonglei Bi, Tae-Hoon Chung, Gaofeng Huang, Jianbiao Zhou, Junli Yan, Gregory J. Ahmann, Rafael Fonseca, Wee Joo Chng, Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma. Oncotarget. ,vol. 6, pp. 26508- 26518 ,(2015) , 10.18632/ONCOTARGET.4769
Yu Shi, Cong Chen, Shi-Zhu Yu, Qing Liu, Jun Rao, Hua-Rong Zhang, Hua-Liang Xiao, Ti-Wei Fu, Hua Long, Zhi-Cheng He, Kai Zhou, Xiao-Hong Yao, You-Hong Cui, Xia Zhang, Yi-Fang Ping, Xiu-Wu Bian, miR-663 Suppresses Oncogenic Function of CXCR4 in Glioblastoma Clinical Cancer Research. ,vol. 21, pp. 4004- 4013 ,(2015) , 10.1158/1078-0432.CCR-14-2807
Muller Fabbri, Mircea Ivan, Amelia Cimmino, Massimo Negrini, George A Calin, Regulatory mechanisms of microRNAs involvement in cancer: the strange case of Dr Jekyll and Mr Hyde Expert Opinion on Biological Therapy. ,vol. 7, pp. 1009- 1019 ,(2007) , 10.1517/14712598.7.7.1009
Haiyan Hu, Shuqin Li, Xiuying Cui, Xiaobin Lv, Yu Jiao, Fengyan Yu, Herui Yao, Erwei Song, Yongsong Chen, Minghui Wang, Ling Lin, The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2) Journal of Biological Chemistry. ,vol. 288, pp. 10973- 10985 ,(2013) , 10.1074/JBC.M112.434340
Tao Yan-Fang, Ni Jian, Lu Jun, Wang Na, Xiao Pei-Fang, Zhao Wen-Li, Wu Dong, Pang Li, Wang Jian, Feng Xing, Pan Jian, The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML). BMC Medical Genetics. ,vol. 14, pp. 74- 74 ,(2013) , 10.1186/1471-2350-14-74
Michael Sand, Marina Skrygan, Daniel Sand, Dimitrios Georgas, Thilo Gambichler, Stephan A. Hahn, Peter Altmeyer, Falk G. Bechara, Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi Cell and Tissue Research. ,vol. 351, pp. 85- 98 ,(2013) , 10.1007/S00441-012-1514-5
Victor Ambros, The functions of animal microRNAs Nature. ,vol. 431, pp. 350- 355 ,(2004) , 10.1038/NATURE02871
A Vislovukh, G Kratassiouk, E Porto, N Gralievska, C Beldiman, G Pinna, A El'skaya, A Harel-Bellan, B Negrutskii, I Groisman, Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744 British Journal of Cancer. ,vol. 108, pp. 2304- 2311 ,(2013) , 10.1038/BJC.2013.243