Early Safety and Efficacy of Percutaneous Left Atrial Appendage Suture Ligation

摘要: Abstract Background Transcatheter left atrial appendage (LAA) ligation may represent an alternative to oral anticoagulation for stroke prevention in fibrillation. Objectives This study sought assess the early safety and efficacy of transcatheter LAA Methods was a retrospective, multicenter consecutive patients undergoing with Lariat device at 8 U.S. sites. The primary endpoint procedural success, defined as success (suture deployment and  Results A total 154 were enrolled. Median CHADS2 score (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke, transient ischemic attack, or thromboembolism [doubled]) 3 (interquartile range: 2 4). Device 94%, 86%. major complication occurred 15 (9.7%). There 14 bleeds (9.1%), driven by need transfusion (4.5%). Significant pericardial effusion 16 (10.4%). Follow-up available 134 median 112 days 50 to 270 days): Death, myocardial infarction, 4 (2.9%). Among 63 acute closure transesophageal echocardiography follow-up, there thrombi (4.8%) 13 (20%) residual leak. Conclusions In this initial experience device, rate high, but limited bleeding. prospective randomized trial is required adequately define clinical efficacy, optimal post-procedure medical therapy, effect operator on safety.