EndoS, a “drug from a bug” as a novel treatment for autoimmunity of the blood

摘要: Pathogens have through co-evolution become the true experts of our immune system and during this process developed a multitude strategies to manipulate response. This is fundamental for pathogens persist cause disease, but we can also exploit nature’s own high throughput screening as source novel biologicals treat disease. We identified several immunomodulating molecules from (PADIMMs) here present one example, immunoglobulin glycan hydrolyzing enzyme EndoS human pathogen Streptococcus pyogenes. hydrolysis IgG completely alters effector functions IgG, with reduced complement activation altered binding Fc-receptors on white blood cells. When taken out its infectious context, be administered an experimental drug in animal models antibody-mediated autoimmunity. been able show that has dramatic positive effects autoimmunity, including rheumatoid arthritis, systemic lupus erythematosus (SLE), particular interest forum, autoimmune hemolytic anemia (AIHA), thrombocytopenic purpura (ITP). The hope is, by telling story, stimulate other researchers join “Drugs Bugs” movement hunt tomorrow.