Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository

摘要: The availability of high-quality human tissues is necessary to advance medical research. Although there are inherent and induced limitations on the use in research, biorepositories play critical roles minimizing effects such limitations. Specifically, optimal utilization research requires be diagnosed accurately, actual specimens provided investigators must carefully described (i.e., quality control each aliquot tissue for including a description any damage tissues). Tissues also should collected, processed, stored, distributed handled) uniformly under rigorous management system (QMS). Frequently, by banks which have stored them standard operating procedures (SOPs). Alternatively, may handled via SOPs that modified specific requirements using prospective biorepository model). primary goal type ensure its high utilized appropriately research; however, approaches vary based available requested. For example, extraction molecules (e.g., microRNA) study molecular characteristics require less clinical annotation than identify how expression might used clarify outcome disease or response therapy. This review focuses design operations can minimize some these