A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response
作者： Alicia A. Bicknell , Anna Babour , Christine M. Federovitch , Maho Niwa
关键词: Unfolded protein response 、 Cell cycle 、 Mutant 、 Saccharomycetales 、 Endoplasmic reticulum 、 Cell biology 、 Cytokinesis 、 Biology 、 Function (biology) 、 Cell growth
摘要: The unfolded protein response (UPR) pathway helps cells cope with endoplasmic reticulum (ER) stress by activating genes that increase the ER's functional capabilities. We have identified a novel role for UPR in facilitating budding yeast cytokinesis. Although other cell cycle events are unaffected conditions disrupt ER function, cytokinesis is sensitive to these conditions. Moreover, efficient requires even during unstressed growth UPR-deficient defective cytokinesis, and mutants activate UPR. likely achieves its sensing small changes load making according capacity. propose one of many cellular require subtle function has previously uncharacterized housekeeping maintaining plasticity normal growth.
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