Haemodynamic and hormonal effects of short-term oestradiol treatment in postmenopausal women

作者: Hannu Luotola , Tapani Pyörälä , Pekka Lähteenmäki , Jarmo Toivanen

DOI: 10.1016/0378-5122(79)90019-7

关键词: Internal medicineSupine positionCardiac outputEndocrinologyHemodynamicsHeart rateBlood volumeStroke volumeBlood pressureMedicineRadiocardiography

摘要: Haemodynamic changes during a 3-wk treatment with oestradiol valerianate (2 mg/day orally) were studied in 12 postmenopausal women by isotope 113Inm radiocardiography. Systolic blood pressure measured the supine position decreased 3% (P less than 0.05) and diastolic 4% 0.01). The heart rate 15% 0.001). Blood volume increased oestrogen 5% whereas cardiac output 9% 0.05). Stroke 13% 0.001) due to concomitant decrease rate. Changes plasma oestrone concentrations substitution showed positive correlation of volume.

参考文章(16)
August Wilhelm von Eiff, E.Jürgen Plotz, Karl J. Beck, Adelheid Czernik, The effect of estrogens and progestins on blood pressure regulation of normotensive women American Journal of Obstetrics and Gynecology. ,vol. 109, pp. 887- 892 ,(1971) , 10.1016/0002-9378(71)90802-7
John H. Laragh, Oral contraceptive-induced hypertension—Nine years later American Journal of Obstetrics and Gynecology. ,vol. 126, pp. 141- 147 ,(1976) , 10.1016/0002-9378(76)90480-4
W.N. Spellacy, S.A. Birk, The effect of intrauterine devices, oral contraceptives, estrogens, and progestogens on blood pressure American Journal of Obstetrics and Gynecology. ,vol. 112, pp. 912- 919 ,(1972) , 10.1016/0002-9378(72)90811-3
S. L. Karonen, P. Lähteenmäki, U. Hohenthal, H. Adlercreutz, Evaluation of the double antibody-solid phase radioimmunoassay technique in plasma LH and FSH and urinary LH measurements. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 38, pp. 97- 106 ,(1978) , 10.1080/00365517809156076
J Kuikka, P Lehtovirta, E Kuikka, A Rekonen, Application of the modified gamma function to the calculation of cardiopulmonary blood pools in radiocardiography Physics in Medicine and Biology. ,vol. 19, pp. 692- 700 ,(1974) , 10.1088/0031-9155/19/5/009
Lars-Eric Edqvist, Elof D. B. Johansson, RADIOIMMUNOASSAY OF OESTRONE AND OESTRADIOL IN HUMAN AND BOVINE PERIPHERAL PLASMA European Journal of Endocrinology. ,vol. 71, pp. 716- 730 ,(1972) , 10.1530/ACTA.0.0710716
P. Lehtov1rta, HAEMODYNAMIC EFFECTS OF COMBINED OESTROGEN/PROGESTOGEN ORAL CONTRACEPTIVES BJOG: An International Journal of Obstetrics and Gynaecology. ,vol. 81, pp. 517- 525 ,(1974) , 10.1111/J.1471-0528.1974.TB00509.X
U. Larsson-Cohn, E. D. B. Johansson, B. Kagedal, L. Wallentin, Serum FSH, LH and oestrone levels in postmenopausal patients on oestrogen therapy. British Journal of Obstetrics and Gynaecology. ,vol. 85, pp. 367- 372 ,(1978) , 10.1111/J.1471-0528.1978.TB14896.X
GUY E. ABRAHAM, RONALD SWERDLOFF, DAN TULCHINSKY, WILLIAM D. ODELL, Radioimmunoassay of Plasma Progesterone The Journal of Clinical Endocrinology and Metabolism. ,vol. 32, pp. 619- 624 ,(1971) , 10.1210/JCEM-32-5-619
S. S. C. YEN, P. L. MARTIN, A. M. BURNIER, N. M. CZEKALA, M. O. GREANEY, M. R. CALLANTINE, Circulating Estradiol, Estrone and Gonadotropin Levels Following the Administration of Orally Active 17β-Estradiol in Postmenopausal Women The Journal of Clinical Endocrinology and Metabolism. ,vol. 40, pp. 518- 521 ,(1975) , 10.1210/JCEM-40-3-518