The pivotal role of nuclear factor erythroid 2-related factor 2 in diabetes-induced endothelial dysfunction

摘要: Endothelial dysfunction (ED) is a key event in the onset and progression of vascular complications associated with diabetes. Regulation endothelial function underlying signaling mechanisms diabetes-induced have been well established. Recent studies indicate that increased oxidative stress an important determinant injury patients hypertension display ED mediated by impaired Nitric Oxide (NO) availability. Further, known to be inflammation remodeling diabetes-associated hypertension. Numerous strategies developed improve cells increasing number evidences highlight indispensable role antioxidants modulation endothelium-dependent vasodilation responses. Nuclear factor Erythroid 2-related 2 (Nrf2), principal transcriptional regulator, central mediating signal response. Having unequivocally established relationship between type diabetes mellitus (T2DM) stress, pivotal Nrf2/Keap1/ARE network, has taken center stage as target for developing therapies towards maintaining cellular redox environment. Several activators Nrf2 are combat few currently clinical trials. Focusing on their therapeutic value ED, this review highlights some natural synthetic molecules involved network its molecular regulation ED. Further emphasis also laid benefits directly up-regulating Nrf2-mediated antioxidant defences regulating homeostasis countering