NSAIDs and risk of colorectal cancer according to presence or absence of family history of the disease.

摘要: Background:We undertook the present analyses to determine whether family history of colorectal cancer in a parent or sibling modifies inverse association nonsteroidal anti-inflammatory drug (NSAID) use with risk. Methods:We used data from two case–control studies cancer. The hospital-based Case Control Surveillance Study included 1526 patients primary cancer, 4192 controls and 6036 noncancer controls. A population-based study conducted Massachusetts enrolled 1201 incident cases community Data on NSAID risk factors for were collected by interview. Results:In both there was reduction odds ratios among subjects who NSAIDs regularly continuing into previous year, regardless history. In Case–Control data, ratio 0.4 (95% CI 0.2–0.9) 0.5 0.4–0.7) without comparable 0.3–0.9) 0.7 0.6–0.9). Conclusions:These indicate that regular is associated reduced persons disease, as well those such