The Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein
作者： Zhaohui Feng , Arnold J. Levine
DOI: 10.1016/J.TCB.2010.03.004
关键词: Warburg effect 、 Metabolic pathway 、 Biology 、 Signal transduction 、 PI3K/AKT/mTOR pathway 、 Transcriptional regulation 、 Oxidative phosphorylation 、 Cell biology 、 Anaerobic glycolysis 、 Protein kinase B
摘要: In response to stress, p53 initiates the transcriptional regulation of selected target genes and various cellular responses, including cell cycle arrest, apoptosis senescence. Recent studies revealed two additional functions in IGF-1/AKT/mTOR pathways energy metabolism, contributing p53's role as a tumor suppressor. Oncogenic processes give rise metabolic focused upon use aerobic glycolysis (the Warburg effect) pentose shunt, providing higher levels reducing activities. shuts down these refocuses cells utilize mitochondrial oxidative phosphorylation, thereby maximizing efficient ATP production minimizing synthesis substrates for division. The alternative is an integral part both normal oncogenic phenotypes.
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