Autophagy regulation in cancer development and therapy.
作者： Candelaria Gomez-Manzano , Erin J White , Vanesa Martin , Juan Fueyo , Sujan Piya
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摘要: Autophagy is a cellular process to degrade long-lived or malfunctioning proteins and obsolete damaged organelles. It maintains homeostasis helps cells survive stressful conditions. Tumor suppressors mostly positively regulate autophagy, whereas oncogene products usually inhibit autophagy. Alterations in key autophagy genes have also been shown affect cancer development. However, the role of depends on status can either suppress promote tumor growth. In present review, we report current state knowledge about reciprocal regulation potential played development therapy.
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