REVIEWS: CURRENT TOPICS Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders

摘要: Soybeans have a high-quality protein that has been consumed for approximately 5000 years in Oriental countries. The awareness soy products are healthy increased their consumption Western Substantial data from epidemiological surveys and nutritional interventions humans animals indicate reduces serum total low-density lipoprotein (LDL) cholesterol triglycerides as well hepatic triglycerides. This review examines the evidence on possible mechanisms which beneficial effects diabetes, obesity some forms of chronic renal disease. Consumption due to low methionine content homocysteine concentration, decreasing risk acquiring cardiovascular On other hand, insulin/glucagon ratio, turn down-regulates expression transcription factor sterol regulatory element binding (SREBP)-1. reduction this decreases several lipogenic enzymes, way LDL very diabetes obesity, reducing lipotoxicity liver. Soy intake also by maintaining number functional adipocytes, preventing transfer fatty acids extra adipose tissues. Furthermore, isoflavones stimulate SREBP-2, increasing clearance. triglyceride concentrations produces kidney inflammatory response, flow releasing endothelial nitric oxide (NO) synthase caveolae, facilitating synthesis NO. Thus, may reduce clinical biochemical abnormalities diseases mediated lipid disorders.