Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases.

摘要: Obesity, the most common nutritional disorder in industrial countries, is associated with increased cardiovascular mortality and morbidity. Nevertheless, molecular basis linking obesity disturbances have not yet been fully clarified. Recent advances biology of adipose tissue indicate that it simply an energy storage organ, but also a secretory producing variety bioactive substances, including leptin adiponectin, may influence function as well structural integrity system. Leptin, besides being satiety signal for central nervous system to be related insulin glucose metabolism, play important role regulating vascular tone because widespread distribution functional receptors cells. On other hand, more recently discovered protein, seems protective experimental models injury, probable relation its ability suppress attachment monocytes endothelial cells, which early event atherosclerotic process. There already considerable evidence altered production some adipocyte hormones complications obesity. Therefore, knowledge alterations endocrine help further understand high risk