Potential Biomarkers Utilized to Define and Manage Overactive Bladder Syndrome.

摘要: Clinical diagnosis of overactive bladder (OAB) syndrome has great variation and usually can only be based on subjective symptoms. Measurement urgency severity score in adjunct with voiding diary may reflect the occurrence OAB incontinence daily life. Urodynamic study detect detrusor overactivity (DO), but not all patients. A more objective way less invasive tool to diagnose assess therapeutic outcome patients is needed. Recent investigations potential biomarkers for include urinary serum wall thickness. Evidence also shown that proteins, such as nerve growth factor (NGF) prostaglandin E2 (PGE2 ) levels increase OAB, outlet obstruction (BOO) DO. Patients have significantly higher NGFlevels NGF decrease after antimuscarinic therapy further botulinum toxin injections. However, sensitivity single protein high several lower tract diseases elevated levels. Searching a group inflammatory by microsphere-based array urine might better method differential from interstitial cystitis, infection (UTI) or urolithiasis. Bladder thickness been widely investigated BOO pediatric dysfunction.The role however, reach consistent conclusion. We hereby review latest medical advances this field.