Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?
作者： Phu Tran , Cham Nguyen , Samuel J. Klempner
关键词: Cancer 、 Signal transduction 、 Breast cancer 、 Neuroendocrine tumors 、 Bioinformatics 、 Kidney cancer 、 Chronic lymphocytic leukemia 、 PI3K/AKT/mTOR pathway 、 Kinase 、 Cancer research 、 Medicine
摘要: Phosphatidylinositol-3-kinase (PI3K) pathway signaling is an established oncogenic signal transduction implicated in multiple malignancies. Therapeutic targeting of PI3K components has improved outcomes chronic lymphocytic leukemia, kidney cancer, breast and neuroendocrine tumors. Gastric cancers harbor some the highest rates alterations but attempts to translate this genomic observation have met with limited clinical success novel approaches are needed. In following review we discuss signaling, previous preclinical investigations gastric future strategies aimed at overcoming resistance improving efficacy. Identification refinement molecular tumor subtypes, development predictive biomarkers along, rational drug combination key capitalizing on therapeutic potential directed therapies cancers.
core.ac.uk
sci-hub.st 参考文章(81)
Zev A. Wainberg, Heloisa P. Soares, Ravi Patel, Brian DiCarlo, David J. Park, Andre Liem, He-jing Wang, Lisa Yonemoto, Diego Martinez, Isett Laux, Meghan Brennan, J. Randolph Hecht, Phase II trial of everolimus in patients with refractory metastatic adenocarcinoma of the esophagus, gastroesophageal junction and stomach: possible role for predictive biomarkers Cancer Chemotherapy and Pharmacology. ,vol. 76, pp. 61- 67 ,(2015) , 10.1007/S00280-015-2744-5
Mei‐Ling Chong, Marie Loh, Bhavin Thakkar, Brendan Pang, Barry Iacopetta, Richie Soong, Phosphatidylinositol‐3‐kinase pathway aberrations in gastric and colorectal cancer: Meta‐analysis, co‐occurrence and ethnic variation International Journal of Cancer. ,vol. 134, pp. 1232- 1238 ,(2014) , 10.1002/IJC.28444
Javier Sastre, Jose Angel García-Saenz, Eduardo Díaz-Rubio, Chemotherapy for gastric cancer. World Journal of Gastroenterology. ,vol. 12, pp. 204- 213 ,(2006) , 10.3748/WJG.V12.I2.204
Ramesh K. Ramanathan, Shannon L. McDonough, Hagen F. Kennecke, Syma Iqbal, Joaquina C. Baranda, Tara E. Seery, Howard J. Lim, Aram F. Hezel, Gina M. Vaccaro, Charles D. Blanke, Phase 2 study of MK‐2206, an allosteric inhibitor of AKT, as second‐line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005) Cancer. ,vol. 121, pp. 2193- 2197 ,(2015) , 10.1002/CNCR.29363
Shuang-Yin Han, Hideaki Kato, Shunsuke Kato, Takao Suzuki, Hiroyuki Shibata, Seiichi Ishii, Ken-ichi Shiiba, Seiki Matsuno, Ryunosuke Kanamaru, Chikashi Ishioka, None, Functional Evaluation of PTEN Missense Mutations Using in Vitro Phosphoinositide Phosphatase Assay Cancer Research. ,vol. 60, pp. 3147- 3151 ,(2000)
William Haenszel, Minoru Kurihara, Studies of Japanese Migrants. I. Mortality From Cancer and Other Diseases Among Japanese in the United States Journal of the National Cancer Institute. ,vol. 40, pp. 43- 68 ,(1968) , 10.1093/JNCI/40.1.43
Peyman Haghighat, Tanios Bekaii-Saab, An update on biochemotherapy of advanced gastric and gastroesophageal adenocarcinoma. Journal of The National Comprehensive Cancer Network. ,vol. 6, pp. 895- 900 ,(2008) , 10.6004/JNCCN.2008.0068
Daniel Cejka, Matthias Preusser, Adelheid Woehrer, Wolfgang Sieghart, Sabine Strommer, Johannes Werzowa, Thorsten Fuereder, Volker Wacheck, Everolimus (RAD001) and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo. Cancer Biology & Therapy. ,vol. 7, pp. 1377- 1385 ,(2008) , 10.4161/CBT.7.9.6416
Naoko Okumura, Hitomi Yoshida, Yasuko Kitagishi, Mutsumi Murakami, Yuri Nishimura, Satoru Matsuda, PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis Advances in Hematology. ,vol. 2012, pp. 843085- 843085 ,(2012) , 10.1155/2012/843085
Jeffrey A. Engelman, Targeting PI3K signalling in cancer: opportunities, challenges and limitations Nature Reviews Cancer. ,vol. 9, pp. 550- 562 ,(2009) , 10.1038/NRC2664