Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and “swarm intelligence”

摘要: Our knowledge of the biology solid cancer has greatly progressed during last few years, and many excellent reviews dealing with various aspects this have appeared. In present review, we attempt to bring together these subjects in a general systems narrative. It starts from roles what term entropy signaling noise initial oncogenic events, first major transition tumorigenesis: independence tumor cell switch its physiology, i.e., subservience organism own independent Darwinian evolution. The development after involves constant dynamic reprogramming cells emergence sort collective intelligence leading invasion metastasis seldom ultimate acquisition immortality through inter-individual infection. At each step, probability success is minimal infinitesimal, but number possibly involved time scale account for relatively high occurrence tumorigenesis multicellular organisms.