Entrainment of a Bacterial Synthetic Gene Oscillator through Proteolytic Queueing

摘要: Internal chemical oscillators (chemical clocks) direct the behavior of numerous biological systems, and maintenance a given period phase among many such may be important for their proper function. However, both environmental variability fundamental molecular noise can cause biochemical to lose coherence. One solution maintaining coherence is entrainment, where an external signal provides cue that resets oscillators. In this work, we study entrainment gene networks by queueing interaction established competition between proteins common proteolytic pathway. Principles are investigated synthetic oscillator in Escherichia coli. We first explore theoretically using standard reaction network model map-based model, which suggest achieved through pulsatile production additional protein competing degradation pathway w...