Models in biology: lessons from modeling regulation of the eukaryotic cell cycle
作者： John J. Tyson , Béla Novák
DOI: 10.1186/S12915-015-0158-9
关键词: Eukaryotic cell 、 Molecular cell biology 、 Biology 、 Cognitive science 、 Extramural 、 Cell biology 、 Mathematical model 、 Cell cycle
摘要: In this essay we illustrate some general principles of mathematical modeling in biology by our experiences studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why models moved from simple, parsimonious cartoons to more complex, detailed mechanisms with many kinetic parameters. describe mature made surprising informative predictions about control system that were later confirmed experimentally. Along way, comment on ‘parameter estimation problem’ conclude an appeal for a greater role biology.
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