Neurotrophic factor for serotogenic neurons prevents degeneration of grafted raphe neurons in the cerebellum
作者： F.C. Zhou , E.C. Azmitia
DOI: 10.1016/0006-8993(90)90286-K
关键词: Hippocampus 、 Raphe 、 5,7-Dihydroxytryptamine 、 Internal medicine 、 Cerebellum 、 Inhibitory postsynaptic potential 、 Neurotrophic factors 、 Endocrinology 、 Biology 、 Transplantation 、 Collateral sprouting
摘要: Abstract Earlier studies in this laboratory have shown that partial serotonergic (5-HT) deafferentation from the hippocampus induced a homotypic sprouting. The 5-HT-denervated was further found to be favorable environment for growth of grafted 5-HT, but not inrepinephrinergic neurons. In current study, we extracted trophic factor denervated with hypotonic solution high-speed supernatant fraction. extract assayed unique experimental paradigm — test 5-HT neurons cerebellum, which receives least innervation, and where seldom survived. diluted (1:200) produced dramatic increase (a) survival rate, (b) fiber-density, (c) 5-hydroxyindoleacetic acids lvels cerebellum. addition, Nissl-counterstaining showed size raphe also apparently increased. concentrated (1:1) did rate These results indicate contains potent neurotrophic can either directly or indirectly support non-5-HT neurons, possibly an inhibitory is present detrimental high concentration.
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