The joining of V and J gene segments creates antibody diversity
作者： Martin Weigert , Robert Perry , Dawn Kelley , Tim Hunkapiller , James Schilling
DOI: 10.1038/283497A0
关键词: Biology 、 Gene 、 Point mutation 、 Immunoglobulin Variable Region 、 Genetics 、 Immunoglobulin light chain 、 Kappa 、 Immunogenetics 、 Molecular biology 、 Antibody Diversity
摘要: The variable regions of mouse kappa (kappa) chains are coded for by multiple (V) gene segments and joining (J) segments. V code residues 1 to 95; the J 96 108 (refs 1-3). This organisation is similar that encoding lambda regions. Diversity in arises from several sources: (1) there germ-line segments; (2) combinatorial with different germline possibly, (3) somatic point mutation, as postulated Also, a comparison number amino acid sequences, it has been suggested region sequences may be determined way joined. report supports this model directly associating various given
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