Cardiac amyloidosis: from clinical suspicion to morphological diagnosis.

摘要: Summary Amyloidosis is a heterogeneous group of diseases characterised by extracellular accumulation amyloid in various tissues and organs the body, leading to alteration destruction tissues. Heart involvement most important prognostic factor patients with systemic amyloidosis diagnosis typing must be made properly. The clinical picture shows congestive heart failure predominant right-sided symptoms fully developed disease, types arrhythmias characteristic electrocardiography echocardiography findings. Blood urine monoclonal protein studies cardiac biomarkers belong spectrum standard laboratory examinations. Cardiac cardiomyopathy connected based on immunoglobulin light chains, serum amyloid A, transthyretin, atrial natriuretic or apolipoprotein A1. In routine diagnostic algorithm, biopsy specimens are examined using special histological staining, immunohistochemistry immunofluorescence; proteomic analysis only performed specialised centres.