Lipid hijacking: a unifying theme in vector-borne diseases
作者： Anya J O'Neal , L Rainer Butler , Agustin Rolandelli , Stacey D Gilk , Joao HF Pedra
DOI: 10.7554/ELIFE.61675
关键词: Infectious disease (medical specialty) 、 Lyme disease spirochete 、 Immune system 、 Biology 、 Borrelia burgdorferi 、 Arthropod Vector 、 Disease severity 、 Pathogenesis 、 Microbiology 、 Plasmodium falciparum
摘要: Vector-borne illnesses comprise a significant portion of human maladies, representing 17% global infections. Transmission vector-borne pathogens to mammals primarily occurs by hematophagous arthropods. It is speculated that blood may provide unique environment aids in the replication and pathogenesis these microbes. Lipids their derivatives are one component enriched essential for microbial survival. For instance, malarial parasite Plasmodium falciparum Lyme disease spirochete Borrelia burgdorferi, among others, have been shown scavenge manipulate host lipids structural support, metabolism, replication, immune evasion, severity. In this Review, we will explore importance lipid hijacking growth persistence microbes both mammalian hosts arthropod vectors.
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