Somatic Mutations and Deletions of the E-Cadherin Gene Predict Poor Survival of Patients With Gastric Cancer

摘要: Purpose The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains primary option in GC treatment. aim this study was to investigate impact somatic CDH1 alterations survival patients with GC. Patients Methods A series sporadic familial (diffuse intestinal; n = 246) were analyzed for mutations, promoter hypermethylation, loss heterozygosity (LOH) by polymerase chain reaction sequencing. E-cadherin protein expression determined immunohistochemistry. Associations between molecular, clinicopathologic, data analyzed. Results found approximately 30% all Both histologic types displayed LOH 7.5%, mutations 1.7%, hypermethylation 18.4% patients. Primary tumors from hereditary diffuse GC, lacking germline alterations, showed exclusively hy...