[18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain.
作者： S. Lavisse , K. Inoue , C. Jan , M. A. Peyronneau , F. Petit
DOI: 10.1007/S00259-014-2962-9
关键词: Quinolinate 、 Chemistry 、 18f dpa 714 、 Translocator protein 、 Pharmacology 、 Pathology 、 Neurodegeneration 、 Radioligand 、 Quinolinic acid 、 Neuroinflammation 、 Pet imaging
摘要: Purpose We aimed to characterize pharmacologically the TSPO- radioligand [18F]DPA-714 in brain of healthy cynomolgus monkeys and evaluate cellular origin its binding a model neurodegeneration induced by intrastriatal injection quinolinic acid (QA).
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sci-hub.se 参考文章(42)
Heinrich R. Schelbert, Michael E. Phelps, John C. Mazziotta, Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart ,(1986)
Tony Wyss-Coray, Tony Wyss-Coray, Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nature Medicine. ,vol. 12, pp. 1005- 1015 ,(2006) , 10.1038/NM1484
Annelaure Damont, Françoise Hinnen, Bertrand Kuhnast, Marie‐Anne Schöllhorn‐Peyronneau, Michelle James, Christopher Luus, Bertrand Tavitian, Michael Kassiou, Frédéric Dollé, Radiosynthesis of [18F]PBR111, a selective radioligand for imaging the translocator protein (18 kDa) with PET Journal of Labelled Compounds and Radiopharmaceuticals. ,vol. 51, pp. 435- 439 ,(2008) , 10.1002/JLCR.1523
Christopher K Glass, Kaoru Saijo, Beate Winner, Maria Carolina Marchetto, Fred H Gage, None, Mechanisms Underlying Inflammation in Neurodegeneration Cell. ,vol. 140, pp. 918- 934 ,(2010) , 10.1016/J.CELL.2010.02.016
Robert J. Ferrante, Neil W. Kowall, P.B. Cipolloni, Elsdon Storey, M.Flint Beal, Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization. Experimental Neurology. ,vol. 119, pp. 46- 71 ,(1993) , 10.1006/EXNR.1993.1006
R. M. Moresco, T. Lavazza, S. Belloli, M. Lecchi, A. Pezzola, S. Todde, M. Matarrese, A. Carpinelli, E. Turolla, V. Zimarino, P. Popoli, A. Malgaroli, F. Fazio, Quinolinic acid induced neurodegeneration in the striatum: a combined in vivo and in vitro analysis of receptor changes and microglia activation European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 35, pp. 704- 715 ,(2008) , 10.1007/S00259-007-0651-7
Abraham Martín, Raphaël Boisgard, Benoit Thézé, Nadja Van Camp, Bertrand Kuhnast, Annelaure Damont, Michael Kassiou, Frédéric Dollé, Bertrand Tavitian, Evaluation of the PBR/TSPO Radioligand [18F]DPA-714 in a Rat Model of Focal Cerebral Ischemia Journal of Cerebral Blood Flow and Metabolism. ,vol. 30, pp. 230- 241 ,(2010) , 10.1038/JCBFM.2009.205
Jae K. Ryu, Hyun B. Choi, James G. McLarnon, Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum Neurobiology of Disease. ,vol. 20, pp. 550- 561 ,(2005) , 10.1016/J.NBD.2005.04.010
I. Dusart, S. Marty, M. Peschanski, Glial changes following an excitotoxic lesion in the CNS—II. Astrocytes Neuroscience. ,vol. 45, pp. 541- 549 ,(1991) , 10.1016/0306-4522(91)90269-T
Masao Imaizumi, Emmanuelle Briard, Sami S. Zoghbi, Jonathan P. Gourley, Jinsoo Hong, Yota Fujimura, Victor W. Pike, Robert B. Innis, Masahiro Fujita, Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors ☆ NeuroImage. ,vol. 39, pp. 1289- 1298 ,(2008) , 10.1016/J.NEUROIMAGE.2007.09.063