Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT.

摘要: Brachial plexus root avulsion (BPRA) leads to dramatic motoneuron death and glial reactions in the corresponding spinal segments at late stage of injury. To protect motoneurons, assessment affected should be done an earlier In this study, we employed 18F-FDG small-animal PET/CT assess severity BPRA-induced cervical cord injuries. Adult Sprague-Dawley rats were randomly treated divided into three groups: Av+NS (brachial (Av) with normal saline), Av+GM1 (treated monosialoganglioside), control. At time points 3 day (d), 1 week (w), 2 w, 4 w 8 post-injury, micro-PET/CT scans neuropathology assessments injured roots, as well cord, performed. The outcomes different treatments compared. results showed that BPRA induced local bleeding typical Wallerian degeneration avulsed roots accompanied by accumulations ipsilateral intervertebral foramen. astrocyte overexpression neuronal nitric oxide synthase motoneurons correlated higher uptake during first post-injury. GM1 treatment reduced inhibited de novo nNOS expressions motoneurons. also protected from within data study suggest could used primary secondary injuries cord. Furthermore, is effective drug for reducing following BPRA.