Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families.

摘要: High-resolution peripheral quantitative computed tomography (HR-pQCT) measures bone microarchitecture and volumetric mineral density (vBMD), important risk factors for osteoporotic fractures. We estimated the heritability (h2 ) of microstructure indices vBMD, measured by HR-pQCT, genetic correlations (ρG among them between regional aBMD dual-energy X-ray absorptiometry (DXA), in adult relatives from Framingham Heart Study. Cortical (Ct) trabecular (Tb) traits were at distal radius tibia up to 1047 participants, ultradistal (UD) was obtained DXA. Heritability estimates, adjusted age, sex, estrogenic status (in women), ranged 19.3% (trabecular number) 82.8% (p < 0.01, Ct.vBMD) 51.9% thickness) 98.3% (cortical cross-sectional area fraction) tibia. Additional adjustments height, weight, radial had no major effect on h2 estimates. In bivariate analyses, moderate high found total vBMD 0.227 0.913), except cortical porosity. At tibia, a similar pattern observed 0.274 0.948), Environmental also substantial. There UD multivariable-adjusted  = 0.811 0.917, respectively). summary, related men women population-based cohort, heritable shared some with These findings HR-pQCT traits, slight attenuation when adjusting aBMD, supports further work identify specific variants underlying fine structure long bones. Knowledge that these are genetically correlated can serve reduce number association studies. © 2016 American Society Bone Mineral Research.