Antiangiogenic agents in cancer therapy

摘要: Part I. Antiangiogenic Factors and Tumor Vasculature. Angiogenesis Blood Flow in the Solid Tumors, Zishan Haroon, Kevin G. Peters, Charles S. Greenberg, Mark W. Dewhirst. Oxygenation of Tumors Animals Patients, Eric Lartigau Marcelle Guichard. Role Inflammatory Mediators Angiogenesis, Federico Bussolino Alberto Mantovani. Intra- Extracellular pH Chang Song, HeonJoo Park, Brian D. Ross. Contribution Matrix Macrophages Peter J. Polverini. Regulation by Organ Microenvironment, Diane R. Bielenberg Isaiah Fidler. Fibroblast Growth Progression Israel Vlodavsky Gerhard Christofori. Vascular Endothelial Factor Napoleone Ferrara. Regulatory Aspects Neovascularization: Wound Metabolic Alterations M. Zamirul Hussain, Q. Perveen Ghani, John Feng, Thomas K. Hunt. II. Agents. Squalamine: A New Angiostatic Steroid, Jon Williams. Cartilage as a Source Natural Inhibitors Vincent Castronovo, Violetta Dimitriadou, Pierre Savard, Marc Riviere, Dupont. Thrombospondin an Inhibitor David Dawson Noel P. Bouk. Metalloproteinase Inhibitors, Brown Whittaker. Angiostatin Other Plasminogen Fragments, B. Kim Lee Sim. Dietary Nutritional Modulation Purna Mukherjee, Jin-Rong Zhou, Alexander V. Sotnikov, Steven Clinton. Thalidomide Analogs,Taturo Udagawa, Henk Verheul, Robert D'Amato. III. In Vivo Studies Clinical Trials. Potentiation Cytotoxic Cancer Therapies Agents, Beverly A. Teicher. Prognostic Significance Vascularity, Gianpietro Gasparini Adrian L. Harris. Endpoints for Determination Efficacy Agents Trials, William Gradishar. Retinoids Interferons Drugs, Clifford, Joseph Miano, Scott Lippman. Pentosan Polysulfate: Polysaccharide That Inhibits Binding Factors, Figg, James Pluda, Oliver Sartor. TNP-470, Deborah Milkowski Rachelle Weiss. Batmastat Marmastat Cancer: Summary Early Data, Henrik Rasmussen. Thalidomide: Prodrug Eddie Reed, Shawn Green, Pluda