Concepts of activated T cell death
作者： Dirk Brenner , Peter H. Krammer , Rüdiger Arnold
DOI: 10.1016/J.CRITREVONC.2008.01.002
关键词: T-cell receptor 、 IL-2 receptor 、 Lymphokine 、 T cell 、 Cell biology 、 Cytotoxic T cell 、 Acquired immune system 、 Biology 、 Immune system 、 T lymphocyte
摘要: Lymphocytes of the adaptive immune system play a crucial role in defending organism against pathogens. Initial stimulation via antigen receptors induces activation and proliferation lymphocytes to generate effector cells that clear pathogen from body. During shut-down response activated are removed by two mechanisms. T restimulated during end die activation-induced cell death (AICD), whereas which not autonomous (ACAD). Here, we discuss regulation AICD ACAD review cytokines, receptor (TCR) proximal signaling mediators like hematopoietic progenitor kinase 1 (HPK1) NF-kappaB pathway. We distinguish between dependent on or independent ligation, caspase-independent cells.
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