Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

摘要: The cellular response to survive or undergo death is fundamental the benefit of organism, and errors in this process can lead autoimmunity cancer. transcription factor nuclear κB (NF-κB) functions block cell through transcriptional induction genes encoding anti-apoptotic antioxidant proteins. This essential for survival activated cells immune system undergoing a DNA damage response. In Ras-transformed tumors as well other cancers, NF-κB suppress apoptosis--a hallmark Critical prosurvival roles inhibitor kinase (IKK) family members, including IKKe TBK1, have been reported, which are both NF-κB-dependent -independent. While promoting lymphocytes cancers relatively clear, evidence has presented that promote particular contexts. Recently, IKK was shown play critical role autophagy, metabolic typically associated with but death. review provides an historical perspective, along new findings, regarding pathways regulating survival.