The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions
作者： Hartmut K??hn , Lawrence Chan
DOI: 10.1097/00041433-199704000-00009
关键词: Cell biology 、 Chemistry 、 Lipoxygenase 、 Transgene 、 Oxidative phosphorylation
摘要: Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action the enzyme. However, recent data obtained with transgenic rabbits overexpressing suggest also antiatherogenic effect. In paper pathophysiological relevance atherogenesis is critically reviewed.
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