Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222.
作者： Stephen N. White , James O. Reynolds , Daniel F. Waldron , David A. Schneider , Katherine I. O'Rourke
DOI: 10.1016/J.GENE.2012.03.068
关键词: Incubation period 、 Flock 、 Biology 、 Transmissible spongiform encephalopathy 、 PRNP 、 Virology 、 Scrapie 、 Incubation 、 Heterozygote advantage 、 Inoculation
摘要: Abstract Scrapie is the transmissible spongiform encephalopathy (TSE) of sheep and goats, scrapie eradication in based part on strong genetic resistance to classical scrapie. Goats may serve as a reservoir, date there has been no experimental inoculation confirming goats. Two prion protein variants (amino acid substitutions S146 K222) goats have significantly underrepresented cases though present scrapie-exposed flocks, demonstrated low cell-free conversion efficiency disease form (PrPD). To test degree conferred live animals with consistent exposure, we performed first oral challenge singly heterozygous for either PRNP or K222. All N146-Q222 homozygotes became clinically positive by an average 24 months, but all K222 heterozygotes remain negative both rectal biopsy clinical signs at longer incubation times (P
core.ac.uk
elsevier.com
sci-hub.se 参考文章(19)
Lynn Herrmann-Hoesing, Janet Alverson, Stephen N. White, Joan Rowe, Daniel Waldron, Katherine I. O'Rourke, Prion gene (PRNP) haplotype variation in United States goat breeds ,(2008)
Penelope Papasavva-Stylianou, Otto Windl, Ginny Saunders, Petroula Mavrikiou, Pavlos Toumazos, Charalambos Kakoyiannis, PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. Veterinary Journal. ,vol. 187, pp. 245- 250 ,(2011) , 10.1016/J.TVJL.2009.10.015
Katherine I O'Rourke, Dongyue Zhuang, Thomas C Truscott, Huijan Yan, David A Schneider, Sparse PrP Sc accumulation in the placentas of goats with naturally acquired scrapie BMC Veterinary Research. ,vol. 7, pp. 7- 7 ,(2011) , 10.1186/1746-6148-7-7
Penelope Papasavva-Stylianou, Marina Kleanthous, Pavlos Toumazos, Petroula Mavrikiou, Phedias Loucaides, Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie. Veterinary Journal. ,vol. 173, pp. 459- 462 ,(2007) , 10.1016/J.TVJL.2005.09.013
T. Lynn, J. Grannis, M. Williams, K. Marshall, R. Miller, E. Bush, S. Bruntz, An evaluation of scrapie surveillance in the United States. Preventive Veterinary Medicine. ,vol. 81, pp. 70- 79 ,(2007) , 10.1016/J.PREVETMED.2007.04.001
I. G. Bouzalas, C. I. Dovas, G. Banos, M. Papanastasopoulou, S. Kritas, A. Oevermann, D. Papakostaki, C. Evangelia, O. Papadopoulos, T. Seuberlich, G. Koptopoulos, Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie. Journal of General Virology. ,vol. 91, pp. 1629- 1634 ,(2010) , 10.1099/VIR.0.017350-0
Stephen White, Lynn Herrmann-Hoesing, Katherine O'rourke, Daniel Waldron, Joan Rowe, Janet Alverson, Prion gene (PRNP) haplotype variation in United States goat breeds (Open Access publication) Genetics Selection Evolution. ,vol. 40, pp. 553- 561 ,(2008) , 10.1186/1297-9686-40-5-553
C. Serrano, M. Hammouchi, A. Benomar, J. Lyahyai, B. Ranera, C. Acín, M. el Hamidi, M. Monzón, J. J. Badiola, N. Tligui, P. Zaragoza, I. Martín-Burriel, PRNP haplotype distribution in Moroccan goats Animal Genetics. ,vol. 40, pp. 565- 568 ,(2009) , 10.1111/J.1365-2052.2009.01873.X
L. Gonzalez, M. Jeffrey, S. SisO, S. Martin, S. J. Bellworthy, M. J. Stack, M. J. Chaplin, L. Davis, M. P. Dagleish, H. W. Reid, Diagnosis of preclinical scrapie in samples of rectal mucosa Veterinary Record. ,vol. 156, pp. 846- 847 ,(2005) , 10.1136/VR.156.26.846-B
Gabriele Vaccari, Michele A Di Bari, Luisella Morelli, Romolo Nonno, Barbara Chiappini, Giovanni Antonucci, Stefano Marcon, Elena Esposito, Paola Fazzi, Nadia Palazzini, Pasquale Troiano, Antonio Petrella, Giovanni Di Guardo, Umberto Agrimi, None, Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie. Journal of General Virology. ,vol. 87, pp. 1395- 1402 ,(2006) , 10.1099/VIR.0.81485-0