Interactions between Brome Mosaic Virus RNAs and Cytoplasmic Processing Bodies
作者： Carla J. Beckham , Heather R. Light , T. Amar Nissan , Paul Ahlquist , Roy Parker
DOI: 10.1128/JVI.00844-07
关键词: RNA-binding protein 、 Virus 、 Brome mosaic virus 、 RNA-dependent RNA polymerase 、 RNA polymerase 、 P-bodies 、 Translation (biology) 、 Biology 、 RNA 、 Genetics
摘要: Cytoplasmic processing bodies are sites where nontranslating mRNAs accumulate for different fates, including decapping and degradation, storage, or returning to translation. Previous work has also shown that the Lsm1-7p complex, Dhh1p, Pat1p, which all components of P bodies, required translation subsequent recruitment replication plant virus brome mosaic (BMV) genomic RNAs when is reproduced in yeast cells. To better understand role BMV replication, we examined subcellular locations We observed RNA2 RNA3 accumulated a manner dependent on cis -acting RNA signals, directed nonviral bodies. Furthermore, viral RNA-dependent polymerase coimmunoprecipitates shows partial colocalization with P-body component Lsm1p. These observations suggest accumulation may be an important step complex assembly BMV, possibly other positive-strand viruses.
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