One-pot Synthesis of Phosphorodiamidothioates Using N-heterocyclic Phosphine (NHP)-thiourea
作者： Ngantu Le , Hai Huang , Jun Yong Kang
DOI: 10.1016/J.TETLET.2018.04.080
关键词: Moiety 、 Medicinal chemistry 、 Thiourea 、 Functional group 、 Leaving group 、 Phosphine 、 One-pot synthesis 、 Reaction conditions 、 Nucleophilic substitution 、 Chemistry
摘要: Abstract N -heterocyclic phosphine (NHP)-thiourea-promoted thiophosphation of thiols has been developed for the synthesis phosphorodiamidothioates under additive-, metal-free reaction conditions. This takes place at room temperature and exhibits good functional group tolerance. The key to success is that thiourea can serve as an excellent leaving group, which tethered with NHP moiety.
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