Pharmacocinétique des anticorps monoclonaux

摘要: The human Fc portion of humanized monoclonal antibodies (mAb) gives them a half-life around 21 days, similar to that endogenous immunoglobulin G (IgG). Neonatal receptor (FcRn) plays major role in the pharmacokinetics (PK) mAbs. By protecting from degradation, it is responsible for their long and by allowing transcytosis, influences absorption distribution. After subcutaneous administration, mAbs slow incomplete. Most are still administered intravenously. Their distribution tissues poorly known. It seems limited certain organs, such as central nervous system, may be protected FcRn. elimination partly mediated binding target-antigen, mechanism leads dose-dependent PK. interindividual variability mAb PK clinically relevant its main known origins demographic factors, antigen mass immunization. Complex models needed describe satisfactorily fate body concentration-effect relationship.