Production of Reactive Oxygen Species and Its Implication in Human Diseases
作者： Shalini Mani
DOI: 10.1007/978-81-322-2035-0_1
关键词: Mitochondrion 、 Cell physiology 、 Electron transport chain 、 Reactive oxygen species 、 Respiratory chain 、 Mitochondrial DNA 、 Superoxide 、 Biochemistry 、 Biology 、 Cell biology 、 Unpaired electron
摘要: Reactive oxygen species (ROS) are chemical molecules with one unpaired electron and mostly derived from molecular oxygen. It is produced in all the mammalian system by various exogenous endogenous sources. Mitochondria major sources of ROS production they as a respiratory by-product. The main sites superoxide radical chain complexes III I; however, other mitochondrial enzymes also involved ROS. Because presence electron, highly reactive, it may cause oxidative damage to biomolecules cell organelles hence affect cellular physiology their survivability.
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