Induction of heat shock proteins by heregulin β1 leads to protection from apoptosis and anchorage-independent growth
作者： Md Abdul Khaleque , Ajit Bharti , Douglas Sawyer , Jianlin Gong , Ivor J Benjamin
关键词: Heat shock protein 、 Heat shock factor 、 Neuregulin 、 Signal transduction 、 GSK-3 、 Cell growth 、 HSF1 、 Apoptosis 、 Biology 、 Cancer research
摘要: Elevation of heat shock protein (HSP) levels is widespread in cancer and predicts a poor prognosis resistance to therapy. We show that HSP elevation tumor cells can be induced by the highly malignant factor heregulin beta1 (HRGbeta1), which induces expression through transcription 1 (HSF1). Inactivation hsf1 gene prevents induction HRGbeta1. cascade response initiated HRGbeta1 binding c-erbB receptors on cell surface leads inhibition intracellular HSF1 antagonist glycogen synthase kinase 3. activated this pathway plays key role protection from apoptosis mediation anchorage independent growth HRGbeta1, indicating for tumorigenic pathway.
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