Autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor in human gliomas with tumor progression.

摘要: Granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage (GM-CSF) and/or their receptors are increasingly detected in solid human tumors, although little is known about function tumor growth invasion. We analyzed RNA protein expression of both factors 22 gliomas (WHO grade II, III, IV) derived cell cultures. G-CSF, GM-CSF, were expressed all tumors cultures, but coexpression was almost exclusively found IV glioblastomas thus correlated with advanced stage. The functional significance G-CSF GM-CSF as regulators for glioma cells demonstrated by 1. stimulation proliferation migration expressing one or the corresponding factor; 2) inhibition neutralizing antibodies to factors. These results indicate a significant role autocrine regulation late-stage malignant suggest shift from paracrine progression. implication glioblastoma could make these further prognostic indicators raises questions concerning use cancer therapy.