Anti-Angiogenic Gene Therapy of Malignant Glioma
作者： A. Stratmann , M. R. Machein , Karl H. Plate
DOI: 10.1007/978-3-7091-6513-3_20
关键词:
摘要: Glioblastoma, one of the best vascularized tumours in humans, appears well suited for an antiangiogenic therapy. VEGF (vascular endothelial growth factor), most important angiogenesis factor identified to date, is highly expressed glioblastoma. particulary upregulated palisading cells adjacent necroses and has subsequently been shown be hypoxia-inducible glioma vitro. VEGF-receptor tyrosine kinases, VEGF-R1 (flt-1) VEGF-R2 (flk-1), are induced a tumour stage dependent manner during progression exclusively vascular cells.
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