Overactive Bladder Syndrome and the Potential Role of Prostaglandins and Phosphodiesterases: An Introduction

摘要: In this paper, a general introduction is given, presenting the overactive bladder syndrome (OAB) and its impact on quality of life economical burden in patients affected. Moreover, anatomy, physiology histology lower urinary tract are discussed, followed by brief overview possible role prostaglandin (PG) phosphodiesterase type 5 (PDE5) bladder. The current literature distribution PGE2 receptors discussed. both animal models human studies, high levels signaling molecules such as PG cGMP have been implicated, decreased functional capacity micturition volume, well increased voiding contraction amplitude. As consequence, inhibition prostanoid production, use receptor antagonists, or PDE inhibitors might be rational way to treat with detrusor overactivity. Similarly, agonists, agents that stimulate their function treating underactivity.