Protective effects of zinc and selenium against benzene toxicity in rats.
作者： Khadiga S Ibrahim , Zeinab A Saleh , Abdel-Razik H Farrag , Eman E Shaban
关键词: Catalase 、 Chemistry 、 Glutathione peroxidase 、 Antioxidant 、 Biochemistry 、 Toxicity 、 Selenium 、 Superoxide dismutase 、 Malondialdehyde 、 Internal medicine 、 Endocrinology 、 Glutathione
摘要: The presented study investigates the protective role of zinc (Zn) and selenium (Se) in attenuating benzene-induced toxicity rats. Male Sprague-Dawley rats were injected with benzene (0.5 mL/kg body weight ip) received a diet supplement containing Zn Se. Several hematological biochemical parameters (representing antioxidant status) estimated. Histopathological examinations performed. Results showed that food intake gain benzene-injected significantly lower than control Benzene-injected increased plasma malondialdehyde (MDA) decreased activity of: glutathione peroxidase (GSH-Px), catalase, superoxide dismutase (SOD) enzymes, as well reduced (GSH) when compared to group. investigations revealed structural changes rats' liver. Supplementation Se resulted significant decrease MDA, elevation GSH, GSH-Px, SOD catalase levels. This shows supplementation can improve enzymes histological anomalies induced by well.
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sci-hub.se 参考文章(47)
Sema Bolkent, Pelin Arda-Pirincci, Sehnaz Bolkent, Refiye Yanardag, Sevim Tunali, Sukriye Yildirim, Influence of zinc sulfate intake on acute ethanol-induced liver injury in rats World Journal of Gastroenterology. ,vol. 12, pp. 4345- 4351 ,(2006) , 10.3748/WJG.V12.I27.4345
H H Sandstead, Understanding zinc: recent observations and interpretations. Journal of Laboratory and Clinical Medicine. ,vol. 124, pp. 322- 327 ,(1994)
Harold H. Draper, William J. Bettger, Role of Nutrients in the Cause and Prevention of Oxygen Radical Pathology Free Radicals in Diagnostic Medicine. ,vol. 366, pp. 269- 289 ,(1994) , 10.1007/978-1-4615-1833-4_19
Ananda S. Prasad, Zinc and Enzymes Springer, Boston, MA. pp. 17- 53 ,(1993) , 10.1007/978-1-4757-9444-1_2
C. B. Ammerman, H. L. Chapman, G. W. Bouwman, J. P. Fontenot, C. P. Bagley, A. L. Moxon, Effect of supplemental selenium for beef cows on the performance and tissue selenium concentrations of cows and suckling calves. Journal of Animal Science. ,vol. 51, pp. 1381- 1386 ,(1980) , 10.2527/JAS1981.5161381X
Roland F. Beers, Irwin W. Sizer, A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. Journal of Biological Chemistry. ,vol. 195, pp. 133- 140 ,(1952) , 10.1016/S0021-9258(19)50881-X
Philip G. Reeves, Forrest H. Nielsen, George C. Fahey, AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet Journal of Nutrition. ,vol. 123, pp. 1939- 1951 ,(1993) , 10.1093/JN/123.11.1939
C. F. Nockels, Vitamin needs increase during stress, disease? Poultry Adviser. ,vol. 23, pp. 49- 53 ,(1990)
D V Parke, Personal reflections on 50 years of study of benzene toxicology. Environmental Health Perspectives. ,vol. 104, pp. 1123- 1128 ,(1996) , 10.1289/EHP.961041123
Ajay Goel, Devinder K Dhawan, Zinc supplementation prevents liver injury in chlorpyrifos-treated rats. Biological Trace Element Research. ,vol. 82, pp. 185- 200 ,(2001) , 10.1385/BTER:82:1-3:185