Ghrelin and Tumors

摘要: Ghrelin production was originally demonstrated in human endocrine cells of the gastric body and pituitary gland, but rapidly shown to occur also several other normal neoplastic cells. Most tumors were found contain ghrelin, as detected by both immunohistochemistry or mRNA analysis. Not only adenomas gastro-entero-pancreatic carcinoids produce pulmonary thyroid tumors. In addition, we have here that nonendocrine lung, breast, colorectal, prostatic, pancreatic carcinomas may well. The significance ghrelin expression is poorly understood, it interest concurrent binding sites occurs many above listed neoplasms. Although one receptor has been cloned so far (the growth hormone secretagogue receptor), data from studies indicate a family receptors probably exists tissues, including These share ability bind acylated nonacylated well synthetic analogs GH family. fact, vitro experiments these compounds displace radiolabeled their antiproliferative effects on tumor cell lines. findings open interesting perspectives control using analogs. However, complete mapping distribution tissues and, all, necessary, together with validation vivo models, better define different growth.